Biomanufacturing process for the production of lactic acid
The CSIR has established a bioconversion platform that focuses on alternative pathways for chemical production. The platform is geared towards local production and replacing imports of bio-based platform chemicals, including lactic acid. This shift will have a direct impact on the bioeconomy. The current bioprocess enables the bioconversion of industrial feedstocks or by-products, such as sugarcane molasses or sugarcane juice, to produce lactic acid by an indigenous microorganism. The technology has evolved from the proof-of-concept stage to achieve a technology readiness level (TRL) of 6. This optimised bioprocess, conducted at a 30 L scale, demonstrates a conversion rate of over 85% for the sugar feedstock into the final product, with titres exceeding 100g/L during the upstream process. Additionally, multiple downstream processing methods have been developed and optimised, resulting in a purified product ranging from 75% to 92%, making it highly suitable for diverse applications across the industrial, food and cosmetic sectors.
An investment of R20 million over two years is required to facilitate the technology’s scale-up, conduct pre-commercial feasibility assessments for integration into existing industries and support business development. Subsequently, there will be a three-year plan for establishing and commissioning a manufacturing plant, projected to cost approximately R60 million.
The anticipated revenue from replacing imports in the local South African lactic acid market is estimated to range from R105 million to R120 million annually. Entry into the global market sector for bioplastics, at a conservative 2% market share, is valued at approximately USD116 million to USD125 million annually.
The technology is available to a local licensee through CSIR C3, offering opportunities as a standalone business or for integration into established commercial industries, including the local sugar industry. Additionally, there is potential for joint ventures with small-scale sugarcane farmers and independent millers. International licensing and commercialisation avenues are also available. The CSIR is committed to facilitating ongoing enhancements and the development of new technologies through research and development partnerships.