The South African Institute for Aquatic Biodiversity (SAIAB) has been exploring marine red algae along the Eastern Cape coastline as a source of novel compounds with potential against breast cancer. These algae, including species such as Laurencia and Gelidium, produce chemically diverse metabolites such as halogenated terpenes, bromophenols, and sulfated polysaccharides.

The Dietary Intake Assessment Application for South Africa (DIASA), developed by the South African Medical Research Council (SAMRC), is a digital tool designed to modernize and streamline the collection, coding, and analysis of dietary intake data for research and public health. By integrating the latest South African Food Composition Tables, culturally relevant portion-size visuals, and user-friendly recall methods, DIASA enhances the accuracy and efficiency of dietary assessment across diverse populations.

The South African Radio Astronomy Observatory (SARAO) is a National Facility managed by the National Research Foundation and incorporates all national radio astronomy telescopes and programmes.

SARAO has established the following projects:
- A GPS Calibrator
- Callosal
- IronHive: Server Array
- Low cost engineered prosthetic limb (foot/lower leg) development
- Personalised HIV Platform

Sawubona Mycelium is a South African biotechnology company harnessing the power of African medicinal fungi to create sustainable, high-value bio-based ingredients for industries such as personal care, functional foods, pharmaceuticals, and beverages. Founded in 2018 and based in Centurion, the company integrates fermentation science, indigenous knowledge, and AI-driven data analytics to unlock novel biomolecules from a library of over 3,000 fungal strains sourced across Southern Africa.