PeeCycling Technologies uses a novel approach to capture and beneficiate human urine. The urine is used to create higher valued products for various applications. The initial product portfolio is focused on liquid fertilizers for agriculture and hydroponics.

The Dietary Intake Assessment Application for South Africa (DIASA), developed by the South African Medical Research Council (SAMRC), is a digital tool designed to modernize and streamline the collection, coding, and analysis of dietary intake data for research and public health. By integrating the latest South African Food Composition Tables, culturally relevant portion-size visuals, and user-friendly recall methods, DIASA enhances the accuracy and efficiency of dietary assessment across diverse populations.

The South African Radio Astronomy Observatory (SARAO) is a National Facility managed by the National Research Foundation and incorporates all national radio astronomy telescopes and programmes.

SARAO has established the following projects:
- A GPS Calibrator
- Callosal
- IronHive: Server Array
- Low cost engineered prosthetic limb (foot/lower leg) development
- Personalised HIV Platform

South African Astronomy Observatory (SAAO) Network's Southern African Large Telescope (SALT) is upgrading its Robert Stobie Spectrograph (RSS) with a new single monolithic CCD detector to replace the old, fragmented one, improving performance and throughput by eliminating chip gaps and leveraging new fringe-suppression techniques. This new detector will be similar to the one used in the RSS-Red arm, with the goal of being operational by early 2026.