The South African Radio Astronomy Observatory (SARAO) is a National Facility managed by the National Research Foundation and incorporates all national radio astronomy telescopes and programmes.

SARAO has established the following projects:
- A GPS Calibrator
- Callosal
- IronHive: Server Array
- Low cost engineered prosthetic limb (foot/lower leg) development
- Personalised HIV Platform

South African Astronomy Observatory (SAAO) Network's Southern African Large Telescope (SALT) is upgrading its Robert Stobie Spectrograph (RSS) with a new single monolithic CCD detector to replace the old, fragmented one, improving performance and throughput by eliminating chip gaps and leveraging new fringe-suppression techniques. This new detector will be similar to the one used in the RSS-Red arm, with the goal of being operational by early 2026.

RIOT Network (Pty) Ltd specializes in producing CROWDNet Nodes, wireless devices enabling households to build local internet infrastructure. Their User-Operated Network Infrastructure model significantly reduces costs for ISPs and MNOs in deploying broadband to underserved areas. With devices already installed in South African communities, RIOT aims to expand affordable internet access, partnering with ISPs, MNOs, and financial institutions to support their growth and enhance digital connectivity nationally.

The South African Institute for Aquatic Biodiversity (SAIAB) has been exploring marine red algae along the Eastern Cape coastline as a source of novel compounds with potential against breast cancer. These algae, including species such as Laurencia and Gelidium, produce chemically diverse metabolites such as halogenated terpenes, bromophenols, and sulfated polysaccharides.