iThemba Laboratories for Accelerator Based Science (LABS) is a business unit of the National Research Foundation (NRF) and committed to invest in the growth and development of scientific and technical competence in the field of accelerator-based science, with a special focus on women and designated communities. iThemba LABS has implemented the following projects:
- iThemba LABS developed an Anti-cancer Radiopharmaceutical Theranostic, a novel conjugated molecule targeting the inhibition of metalloprotease (ADAM10) s a cell-surface-expressed metalloproteinase. It is a type of protein enzyme with

The South African Radio Astronomy Observatory (SARAO) is a National Facility managed by the National Research Foundation and incorporates all national radio astronomy telescopes and programmes.

SARAO has established the following projects:
- A GPS Calibrator
- Callosal
- IronHive: Server Array
- Low cost engineered prosthetic limb (foot/lower leg) development
- Personalised HIV Platform

The South African Institute for Aquatic Biodiversity (SAIAB) has been exploring marine red algae along the Eastern Cape coastline as a source of novel compounds with potential against breast cancer. These algae, including species such as Laurencia and Gelidium, produce chemically diverse metabolites such as halogenated terpenes, bromophenols, and sulfated polysaccharides.