The South African Radio Astronomy Observatory (SARAO) is a National Facility managed by the National Research Foundation and incorporates all national radio astronomy telescopes and programmes.

SARAO has established the following projects:
- A GPS Calibrator
- Callosal
- IronHive: Server Array
- Low cost engineered prosthetic limb (foot/lower leg) development
- Personalised HIV Platform

South African Astronomy Observatory (SAAO) Network's Southern African Large Telescope (SALT) is upgrading its Robert Stobie Spectrograph (RSS) with a new single monolithic CCD detector to replace the old, fragmented one, improving performance and throughput by eliminating chip gaps and leveraging new fringe-suppression techniques. This new detector will be similar to the one used in the RSS-Red arm, with the goal of being operational by early 2026.

The South African Institute for Aquatic Biodiversity (SAIAB) has been exploring marine red algae along the Eastern Cape coastline as a source of novel compounds with potential against breast cancer. These algae, including species such as Laurencia and Gelidium, produce chemically diverse metabolites such as halogenated terpenes, bromophenols, and sulfated polysaccharides.

Sensor Networks is a South African smart-technology company founded in 2007 that blends hardware, software and data analytics to deliver intelligent home and business solutions. They focus on energy management, risk mitigation (especially for water and geyser systems), smart home automation, and custom hardware & development.